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Fecal microbiota transplantation: an update on the advances in the treatment of complex diseases

  • Carlotta Magrì1, Giuliana Calabrese1, Letizia Masi2, Sara Troisi1, Federica di Vincenzo1, Pierluigi Puca1, Cristina Graziani2, Loris R. Lopetuso2,3,4, Valentina Petito2

1Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
2Centro per le Malattie dell’Apparato Digerente (CeMAD), UOS di Malattie Infiammatorie Croniche Intestinali, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy.
3Dipartimento di Medicina e Scienze dell’Invecchiamento, Università degli studi “G. D’Annunzio”, Chieti-Pescara, Chieti, Italy.
4Center for Advanced Studies and Technology (CAST), Università degli studi “G. D’Annunzio”, Chieti-Pescara, Chieti, Italy.

  • Nutr Cur 2023; 02: e001
  • DOI: 10.57625/nec.2022.23

ABSTRACT

In addition to its proven effectiveness in the treatment of recurrent Clostridium difficile infections (rCDI), fecal microbiota transplantation (FMT) is on the rise to become one of the most studied innovative therapies for the treatment of several complex diseases. This review aims to discuss the many promising applications of FMT in intestinal diseases such as inflammatory bowel diseases (IBD) and extraintestinal diseases such as neuropsychiatric disorders, metabolic syndrome, and autoimmune diseases. For each disease group, preclinical data will be presented in addition to clinical trial evidence.

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Corresponding author:

  • Valentina Petito
  • To cite this article: Magrì Carlotta, Calabrese Giuliana, Masi Letizia, Troisi Sara, Di Vincenzo Federica, Puca Pierluigi, Graziani Cristina, Lopetuso Loris R., Petito Valentina. Fecal microbiota transplantation: an update on the advances in the treatment of complex diseases. Nutr Cur 2022; 01: e131 - DOI: 10.57625/nec.2022.23

Publication history:

Submission date: 8th Dec, 2022
Revised on: 12th Dec, 2022
Accepted on: 15th Dec, 2022
Published online: 10th Jan, 2023

  • This work is licensed under a Creative Common Attribution-NonCommercial-ShareAlike 4.0 International License
  • Category: Review
  • Topic: Fecal microbial transplantation

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Nutrimentum et Curae focuses on all issues related to body and mind health maintenance, and the search for all strategies – pharmacological and non-pharmacological – to find optimal nutritional and behavioral patterns for the population.

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